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Another
concern is misprescription, such as the prescribing by gastroenterologists
and other specialists pancreatic enzyme (brand names Festal, from
Hoechst, nad Zymet, from Beximco) and oxiphenomonium bromide (brand
name Antreny1, from Ciba -Geigy) for indigestion. Some brands are
more misused than others in the same category of drugs, obviously
because of heavy promotion. Interestingly, drugs of doubtful efficacy
are highly priced. A 250 mg tablet of ciprofloxacin, a useful drug
but wrongly prescribed for ordinary fevers of two to three days'
duration and for diarrhea, cost Taka 12 in 1994, whereas cotrimoxazole
cost just over Taka 1 per tablet, Similarly a 300 mg ranitidine
tablet was priced at Taka 4, while 20 mg of omeprazole cost Taka
14, Not only do bribes in the form of gifts, or travel and per diem
expenses for attendance at seminars, increase the irrational prescription
of drugs, they also add to the cost of these unnecessary drugs.
An extensive
study of prescribing habits of GPs paediatricians in Indonesia,
undertaken in 1988 by the Indonesian Consumer Federation found that
GPs wrote fewer drugs per prescription than paediatricians. paediatricians
also often wrote two or more antibiotics in the same prescription
(in 21.1 per cent of cases compared with 12.4 per cent for GPs).
GPs prescribed two or more vitamins (15.8 per cent) and two or more
antidiarrhoeal drugs (31.6 per cent ) in the same prescription,
a higher incidence than for paediatricians. But oral rehydration
therapy (ORT), generally acknowledged to be the most important and
effective form of treatment for diarrhea, had been prescribed in
only 16.03 percent of all the cases.
Source: Chowdhary, zafrullah. The politics of Essential Drugs,
op.cit.,pp.124-126. |
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Combination Drugs
According to the
WHO Expert Committee (2) combination drugs should not be used
unless there are no alternative single drug available for treatment
or no alternative single drug was cost-effective for the purpose.
Expert recommended that patients be individually evaluated and
those patients requiring more than one drugs should be prescribed
separately. Combination drugs "increase the risk of side
effect and may also needlessly increase cost while encouraging
irrational miss and hit'
therapy" (3). When a combination drug is used it is difficult
to identify a which drug is the cause of a drug reaction. Combination
drugs are irrational also because their stability is doubtful,
reducing the efficacy in many reparations. Moreover, drug companies
frequently change the ingredients making is difficult to keep
track of the changes.
|
| Injections
with combinations of streptomycin ( for the treatment of T.B.) and
penicillin since banned have been widely used in the treatment of
fevers, infections and other minor illnesses. This is irrational
because it masks the occurrence of T.B. and leads to the development
of resistance to streptomycin by T.B. Bacilli (mycobacterium tuberculosis).
Similarly, streptomycin in combination with chloramphenicol |
|
was widely (mis )used in the treatment of diarrhoes ( the combination
has been banned since 1988 after attempts by affected drug companies
to thwart a ban). This used to be a sheer waste as 60 per cent
of diarrhea is viral and can be controlled by Oral Rehydration
Therapy and do no need anto-bacterials. Indiseriminate use of
chlormphenicol itself is hazardous because it unnecessarily exposes
people to the risks of chloramphenicol, for example fatal blood
discorders like agranulocytosis, a drug which should be reserved
for typhoid fevers. Used in combination, it causes resistance
of typhoid to the drug.
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Irrational drug combinations include
| * |
|
Antibiotics
combined with other antibiotics or with cortico- steroid or other
active substances such |
| |
|
as
vitamins. |
|
| * |
|
Combination
of antipyretics and analgesics, e.g. ibuprofen + paracetemol or
analgin |
| |
|
+
paracetemol. |
|
| * |
|
Analgesics
combined with iron, vitamins or alcohol. Combination painkillers
increase |
| |
|
the
risk of toxicity and other side-effects, especially kidney damage.
Analgesics |
| |
|
combined
with iron or vitamins are irrational and wasteful; analgesics combined
with |
| |
|
alcohol
are wasteful and potentially dangerous. |
|
| * |
|
Codeine in combination with other medicines; since codeine is a
habit forming drug |
| |
|
and
using it in combination medicines increases the risk of addiction. |
|
| * |
|
"Multi"
and liquid vitamin preparations, with the exception of combination
vitamins |
| |
|
supplied
in small bottles, with droppers for babies. |
The guidelines as per
the WHIO recommendations for acceptability of Fixed Dose Combinations
are :
|
1.
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Clinical
documentation justifies the concomitant use of more than one drug. |
|
|
2.
|
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Therapeutic
effect is greater than the sum of the effect of each. |
|
|
3.
|
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The cost
of combination product is less than the sum of individual products. |
|
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4.
|
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Compliance
is improved (the is when two or more medicines are to be taken separately, |
| |
|
as in
the case of TB, the user tends to avoid one or two medicines aftersometime.
This |
| |
|
can be
avoided if all three medicines are combined into one). |
|
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5.
|
|
Sufficient
drug ratios are provided to allow dosage adjustments satisfactory
for the |
| |
|
majority
of the population. |
Any fixed dose combination
which does not satisfy the above mentioned guidelines is considered
irrational (5). (See also Appendix 2: Why some leading drug combinations
in the Indian market should not be sold- but are still sold).
When Drug Combination
are Rational
Drug combinations in some cases are not only rational but are sometimes
even necessary. The scientific rationale of few selected drug combinations
is given below::
|
1.
|
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When it
allows synergistic action, i.e., it facilitates each other's
pharmacological action, thereby |
| |
|
producing
greater effects.. |
| |
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|
2.
|
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Where
it allows enhanced efficacy without linking of each other's
pharmaco-chemical actions. |
| |
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3.
|
|
Combined
doses are given in cases of general under-nourishment or simultaneous
deficiency of all |
| |
|
vitamins
in famine conditions, e.g., Vitamin B complex, multivitamin,ferrous
sulfate + folic acid, |
| |
|
Vitamin
A + Vitamin D. |
| |
|
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4.
|
|
Where
it is necessary to reduce side-effects or toxicity, e.g., isonex
+ Vitamin B6 (Vitamin B6 |
| |
|
prevents
peripheral neuritis caused by prolonged use of isonex). |
|
There
are also some simple ways of monitoring drug use. See for example the box
below on Core Drug Use Indicators. (See also Phadke, et.al. op.cit. for
a critique of these criteria).
| |
|
Core
Drug Use Indicators
|
| |
Prescribing
indicators |
| |
1. |
Average
number of drugs per encounter |
| |
2.
|
Percentage of encounters with an antibiotic prescribed |
| |
3. |
Percentage
of drugs prescribed by generic name |
| |
4.
|
Percentage
of encounters with and injection prescribed |
| |
5. |
Percentage
of drugs prescribed from essential drugs list or formulary |
| |
Patient
care indicators |
| |
6. |
Average consultation time |
| |
7. |
Average dispensing time |
| |
8. |
Percentage of drugs actually dispensed |
| |
9. |
Percentage of drugs adequately labeled |
| |
10.
|
Patient's
knowledge of correct dosage |
| |
Facility
Indicator |
| |
11. |
Availability of copy essential drugs list or formulary |
| |
12. |
Availability of key drugs |
| |
Source:
How to Investigate Drug Use in Health Facilities: Selected Drug Use
of Indicators. Action Programme of Essential Drug, WHO, Geneva, 1993.
|
|
Vitamins and Tonics |
| These
are some of the most highly selling and highly-priced products in India. |
|
Vitamin and tonics are in
many cases a mixture of Vitamin B-complex or vitamins in solutions of
sugar and alcohol. Tonics or health restoratives are prescribed for debilitating
conditions usually for convalescents, chronic diseases, loss of appetite,
weight loss, and fatigue.
|
|
Vitamin and tonic preparations
are irrational because what is actually needed is an adequate mixed diet
containing leafy vegetables. Vitamin deficiency should be treated with
specific vitamins in dry tablet form.
|
|
Tonics are hazardous when
substances like caffeine, strychnine, leptazol are combined with vitamins.
Regular intake of Vitamin A and D will be excessive and hence hazardous.
|
|
Bangladesh has banned tonics,
enzyme mixtures/preparations and restorative product because such products
"flourish on consumer ignorance..., most are habit-forming and with
the exception of pancreatin and lactase (which are allowed as single ingredient
products) of no therapeutic value." (6). United Kingdom does not
recognise tonics as drugs.
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|
Most of the tonics are grossly
advertised with many tall claims as health restoratives. However they
often contain inadequate doses of vitamins, useless ingredients and lot
of alcohol. A well known tonic, Waterbury's
Yellow Label tonic, contains about 3 mg of Iron per teaspoon of which
only one-tenth is absorbed by the body. The Indian Council of Medical
Research recommends at least a daily intake of 10 mg for men and 20-30
mg for an average woman.
|
|
Some tonic preparations contain
more vitamins than what is actually needed. High-potency multivitamin
formulations are sheer waste of resources as they are almost wholly rejected
by the body, particularly in the case of well-fed consumers. The daily
requirement of the human body of Vitamin C is about 50 milligram, of Vitamin
B1 one milligram and some others in minute quantities of few milligrams.
Yet tonic preparations, apart from being extremely expensive, contain
between 10 to 50 times the minimum requirements which are simply excreted
by the body. Moreover, most vitamins are needed in small amounts to stimulate
metabolism, they are not energy-enhancers.
|
|
The daily requirements of
Vitamin C can be obtained from regular use of fruits or fresh vegetables
and salad helpings. Vitamin A, supplied by green leafy vegetables, is
stored in large amounts by the body for proper vision. Vitamin D is naturally
synthesized by the skin from daily sunlight. Despite the availability
of inexpensive, fresh fruits and vegetables, tonics are a craze among
people. Over 15, 000 tonnes of health drinks are produced every year in
India. Manufacturers spend large amount of money on advertisement. Television
advertising is a very effective way of getting credulous consumers hooked
on these expensive junk. And the current trend is to recommend tonics
for healthy adults and growing children.
|
|
The production of the high-potency
or Forte preparation of multivitamins is a sheer economic waste. It is
a drain on the consumers and government dispensaries. It would benefit
more number of patients if the preparation was made available in smaller
but adequate quantities so that more tablets could be produced at cheaper
price. High-potency preparation is also a drain on the country's
foreign exchange as most of the raw materials have to be imported.
|
|
Cough Syrups and expectorants
are mixtures of drugs which stimulate coughing (ammonium chloride, ipecac)
as well as those which suppress coughing (codeine, noscapine) and antihistamines
that dry the secretions (some common brand names are Benadryl Expectorant,
Piriton Expectorant, Avil Expectorant).
|
| Prolonged
use of cough syrup is habit-forming, it may cause stomach upsets, reduce
food intake and cause drowsiness. |
| Coughing
is a protective activity of the body. It should not be suppressed except
in certain conditions. Simple steam inhalation is advised. If it is necessary
to use drugs, use only a single ingredient cough suppressants such as codeine,
dextromethorphan. There is no scientific basis for using cough suppressants
and cough stimulants together. |
|
The WHO List of Essential
Drugs does not include cough syrups and lozenges. Bangladesh has banned
them on the grounds they are "of little or no therapeutic value and
amounts to great wastage of meager resources"(7).
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